Immunosuppressive enzymes in the tumor microenvironment
نویسندگان
چکیده
منابع مشابه
Reg3β contributes to the immunosuppressive tumor microenvironment in pancreatic cancer
Reg3β is up-regulated in serum and pancreatic juice from patients with pancreatic ductal adenocarcinoma. However, whether such expression is relevant to the development of tumors has not yet been carefully examined. We have recently demonstrated that silencing Reg3β in a pancreatic cancer model impaired tumor growth by skewing macrophage polarization. Pancreatic ductal adenocarcinoma (PDAC) con...
متن کاملImmunosuppressive Microenvironment in Neuroblastoma
According to the cancer immunoediting model, the interplay between tumor cells and the host immune system is crucial for the control of tumor growth. NB is a pediatric tumor that presents with metastatic disease at diagnosis in about 50% of the cases, the majority of which have poor prognosis. In this Review article, immune escape pathways adopted by human neuroblastoma (NB) cells are reviewed....
متن کاملMolecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment.
The endoplasmic reticulum (ER) is a massive cytoplasmic membrane network that functions primarily to ensure proper folding and posttranslational modification of newly synthesized secreted and transmembrane proteins. Abnormal accumulation of unfolded proteins in this organelle causes a state of "ER stress," which is a hallmark feature of various diseases, including cancer, neurodegeneration, and...
متن کاملMolecular Pathways: Immunosuppressive Roles of IRE1a-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment
The endoplasmic reticulum (ER) is a massive cytoplasmic membrane network that functions primarily to ensure proper folding and posttranslational modification of newly synthesized secreted and transmembrane proteins. Abnormal accumulation of unfolded proteins in this organelle causes a state of "ER stress," which is a hallmark feature of various diseases, including cancer, neurodegeneration, and...
متن کاملUbiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely understood. Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its role in tumor microenvironment regulation is poorly characterized. PML is frequently downregulated ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 2017
ISSN: 0014-5793
DOI: 10.1002/1873-3468.12784